Hence, a thorough understanding of the molecules involved in the process of glia migration may contribute to the development of therapeutics for these pathologies. Defective glia migration is associated with several human diseases including glial brain tumors and defective regeneration following injury in the nervous system ( Klämbt, 2009 Kocsis and Waxman, 2007 Oudega and Xu, 2006). Glia migrate collectively and over long distances to establish an intricate relationship with neurons. Neurons and glia show mutual reliance in many functional and developmental aspects of biology. Our model includes strict spatial localization of a ligand, a cell autonomously acting receptor and a fate determinant that act coordinately to direct glia toward their final destination. NetrinB but not NetrinA serves as a chemoattractant and Unc5 contributes as a repellant Netrin receptor for glia migration. Thus, the glial determinant also regulates the efficiency of collective migration. Frazzled expression is induced by the transcription factor Glide/Gcm in a dose-dependent manner. Here, we show that the timely and threshold expression of the Netrin receptor Frazzled triggers the initiation of glia migration in the developing Drosophila wing. Several molecules implicated in cell interactions also control collective migration, but their precise role and the finely tuned expression that orchestrates this complex developmental process are poorly understood. Collective migration is a complex process that contributes to build precise tissue and organ architecture.
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